Publications

A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus

Published in Appetite, 2022

We have provided a detailed comparison of Glp1r and Gipr cells of the hypothalamus with single-cell resolution. This resource will provide mechanistic insight into how engaging Gipr- and Glp1r-expressing cells of the hypothalamus may result in changes in feeding behaviour and energy balance.

Recommended citation: Smith C, Patterson-Cross R, Woodward O, Lewis J, Chiarugi D, Merkle F, Gribble F, Reimann F, Adriaenssens A. A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus. Appetite. 2022 Jul 1;174:106022. doi: 10.1016/j.appet.2022.106022. Epub 2022 Apr 14. PMID: 35430298; PMCID: PMC7614381.

A Comparison of the Cellular and Molecular Atlases of the Macaque and Mouse Dorsal Horns

Published in Neuron, In Press, 2021

The study thus provides an essential resource for the functional interrogation of neural circuits underlying somatosensory processing within the dorsal horn and across species as well as for the validation of therapeutic targets.

Recommended citation: Arokiaraj, Cynthia Mary and Kleyman, Michael and Chamessian, Alexander and Shiers, Stephanie and Kang, Byungsoo and Kennedy, Meaghan M. and Patterson, Ryan and Lewis, David A. and Qadri, Yawar and Levine, Ariel J. and Price, Theodore and Pfenning, Andreas R. and Seal, Rebecca P., A Comparison of the Cellular and Molecular Atlases of the Macaque and Mouse Dorsal Horns. Available at SSRN: https://ssrn.com/abstract=3924596 or http://dx.doi.org/10.2139/ssrn.3924596

A Harmonized Atlas of Spinal Cord Cell Types and Their Spatial Organization

Published in Nature Communications, 2021

This work provides an unprecedented view of spinal cell types, their specific gene expression signatures, and the general molecular organization.

Recommended citation: Russ DE, Cross RBP, Li L, Koch SC, Matson KJE, Yadav A, Alkaslasi MR, Lee DI, Le Pichon CE, Menon V, Levine AJ. A harmonized atlas of mouse spinal cord cell types and their spatial organization. Nat Commun. 2021 Sep 29;12(1):5722. doi: 10.1038/s41467-021-25125-1. Erratum in: Nat Commun. 2022 Feb 18;13(1):1033. Erratum in: Nat Commun. 2022 Oct 19;13(1):6184. PMID: 34588430; PMCID: PMC8481483.

Selecting single cell clustering parameter values using subsampling-based clustering metrics

Published in BMC Bioinformatics, 2021

Here, we illustrate a subsampling-based approach (chooseR) that simultaneously guides parameter selection and characterizes cluster robustness.

Recommended citation: Patterson-Cross RB, Levine AJ, Menon V. Selecting single cell clustering parameter values using subsampling-based robustness metrics. BMC Bioinformatics. 2021 Feb 1;22(1):39.

Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices

Published in Journal of Neuroscience, 2015

Our results suggest that loss of vision produces distinct circuit changes in the spared and deprived sensory cortices to shift between feedforward and intracortical processing to allow adaptation.

Recommended citation: Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, Lee HK. (2015). "Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices." J Neurosci. 35(23).